Survival horror is as much about resource management as it is about dodging zombies. In the Resident Evil 2 Remake, the difference between having enough shotgun shells for a boss fight and running on empty often comes down to one thing: opening every locked container. Finding every RE2 safe code and locker combination provides essential upgrades, from weapon parts that stabilize your aim to hip pouches that expand your inventory.

This collection details every combination for both Leon and Claire, covering the Raccoon City Police Department, the Sewers, and the NEST laboratory. Since some solutions change during a Second Run (B Scenario), those variations are specified to ensure no lock remains closed.

Raccoon City Police Department (RPD) Safe Codes

The RPD is the heart of the game and contains the most rewarding safes. These safes require a specific sequence of turns—left, right, and left again. Unlike some modern games, you do not need to find the in-game clue to input the code; if you know the numbers, you can open them immediately.

West Office Safe (1F)

  • Combination: Left 9, Right 15, Left 7
  • Location Detail: Located in the small side office within the West Office on the first floor. It is tucked in the corner behind the desk.
  • Reward: Hip Pouch (increases inventory by 2 slots).
  • Why it matters: This is arguably the most important safe in the game. Inventory space is at a premium in the early stages, and getting those two extra slots before exploring the darker corners of the station changes the pace of the game.

Waiting Room Safe (2F)

  • Combination: Left 6, Right 2, Left 11
  • Location Detail: Found in the East Wing's Waiting Room. It sits behind the counter, clearly visible to anyone entering the room.
  • Reward (Leon): Muzzle Brake for the Matilda handgun.
  • Reward (Claire): High Capacity Mag for the JMB Hp3.
  • Why it matters: Improving the Matilda's recoil or the JMB's magazine size provides a significant tactical advantage when dealing with the crowds of zombies in the hallways.

Treatment Pool Room Safe (Sewers)

  • Combination: Left 2, Right 12, Left 8
  • Location Detail: This safe is located in the Middle Level of the Sewers. You will find it in the Treatment Pool Room.
  • Reward (Leon): Shotgun Stock for the W-870.
  • Reward (Claire): Reinforced Frame for the SLS 60.
  • Why it matters: The Shotgun Stock reduces recoil and increases the rate of fire, making Leon's primary crowd-control weapon much more effective. Claire's frame allows the SLS 60 to fire High-Powered Rounds, turning a simple revolver into a handheld cannon.

RPD Locker Combinations

Lockers utilize a three-letter dial lock. These are generally easier to find than safe codes but are often guarded by more dangerous enemies.

3F Stairs Locker

  • Combination: DCM
  • Location Detail: Located at the top of the stairs on the third floor of the West Wing. Watch out for the shadow of a hanging zombie nearby.
  • Reward (Leon): Magnum Ammo.
  • Reward (Claire): Submachine Gun Ammo.
  • Strategy Tip: Don't open this until you actually have the weapon. Saving high-tier ammo for later is better than letting it clog your inventory early on.

Men’s Locker Room (2F)

  • Combination: CAP
  • Location Detail: Inside the locker room where the steam is leaking from a broken pipe. The locker is on the right side of the room.
  • Reward (Leon): Shotgun Shells.
  • Reward (Claire): Flame Rounds.
  • Strategy Tip: These rewards are essential for the first major boss encounter. Ensure you grab these before heading down into the parking garage.

Sewer Control Room Locker

  • Combination: SZF
  • Location Detail: Found in the Upper Level of the Sewers. You will enter this room as part of the main path.
  • Reward (Leon): Magnum Ammo.
  • Reward (Claire): Submachine Gun Ammo.

Leon’s Desk: The Rookie’s First Assignment

One of the first puzzles you encounter involves two locks on Leon’s desk in the West Office (1F). The clues are found on the desks of his fellow officers, using the first letter of their first names.

  • Left Lock: NED
  • Right Lock: MRG
  • Reward (Leon): High-Capacity Mag (Matilda).
  • Reward (Claire): Speed Loader (SLS 60).

Opening this desk early is vital. Claire’s speed loader is especially transformative, as the base reload speed of the SLS 60 is dangerously slow when being chased by Mr. X.

Medallion Statue Puzzles (RPD)

To escape the RPD, you need three medallions. The solutions for these statues change significantly depending on whether you are playing a First Run (Scenario A) or a Second Run (Scenario B).

Lion Statue (Main Hall 2F)

  • First Run Solution: Lion, Leafy Branch, Bird
  • Second Run Solution: Crown, Torch, Bird

Unicorn Statue (Lounge 1F)

  • First Run Solution: Fish, Scorpion, Vase
  • Second Run Solution: Two People, Scales, Uncoiled Snake

Maiden Statue (West Storage Room 3F)

  • First Run Solution: Woman, Bow, Snake
  • Second Run Solution: Ram, Harp, Bird
  • Note: The icons on the Maiden statue are often rusted or dirty. You must look closely at the remaining details of the symbols to align them correctly.

The Greenhouse and Laboratory Codes

In the NEST laboratory, you will encounter a terminal in the Greenhouse Control Room. Instead of numbers or letters, it uses strange alien-like symbols. For ease of use, imagine the terminal is a standard 1-9 keypad (like a phone).

Greenhouse Ladder Code

  • First Run: 3, 1, 2, 3
  • Second Run: 5, 8, 3, 1
  • Purpose: Unlocks the ladder in the greenhouse, allowing access to the lower levels of the lab.

Drug Testing Lab Code

  • First Run: 2, 0, 6, 7
  • Second Run: 2, 0, 4, 8
  • Purpose: Unlocks the dispersal unit that allows you to synthesize the herbicide needed to deal with Plant 43.

Advanced Puzzle Solutions

Beyond simple codes, several multi-step puzzles require specific combinations to proceed. These are often the biggest stumbling blocks for players.

Chess Plug Puzzle (Sewers)

This puzzle requires placing six chess pieces (King, Queen, Rook, Bishop, Knight, Pawn) into specific sockets. The orientation is based on the wall facing the desk.

First Run (Scenario A):

  • Right Wall: Pawn, Queen, King
  • Left Wall: Bishop, Rook, Knight

Second Run (Scenario B):

  • Right Wall: Pawn, Rook, Knight
  • Left Wall: Queen, Bishop, King

Herbicide Synthesis (NEST Lab)

Once you have the dispersal cartridge and the codes above, you must mix the solution by moving liquids between different-sized tubes. The goal is to hit the target line precisely.

First Run (Scenario A): Red, Green, Blue, Red, Green, Blue, Red, Green

Second Run (Scenario B): Blue, Red, Green, Red, Blue, Red, Blue, Green, Blue, Red, Green

(Note: For this puzzle, Red represents the middle button, Green the left, and Blue the right.)

The Importance of the Portable Safes

You will find two Portable Safes during your exploration of the RPD. Unlike the fixed safe codes, these do not have a set solution. They are randomized for every playthrough. To open them, you must press the buttons in a sequence that lights up the circle in a counter-clockwise direction.

Opening both portable safes rewards you with two Spare Keys. These keys are used in the Safety Deposit Room (1F). If you place both keys in the terminal, you can unlock every locker in the room, including Locker 203, which contains another Hip Pouch.

Strategic Recommendations for Using Codes

Knowing the RE2 safe codes allows for a level of "sequence breaking" that can make Hardcore difficulty significantly easier. For instance, Leon can obtain the Shotgun Stock almost immediately upon reaching the Sewers if the player knows the Treatment Pool safe code, without having to find the "Jazz Festival" flyer that contains the clue.

Furthermore, players should prioritize the Hip Pouches found in the West Office and the Safety Deposit Room. Managing healing items, ammo, and key items becomes increasingly difficult as the game progresses into the Sewers and the Lab. By using these codes as soon as you reach the respective rooms, you minimize backtracking through dangerous areas where enemies like the Lickers or the Tyrant may be patrolling.

Another critical tip involves the disposal of key items. Once a safe is opened or a puzzle is solved, the map will often mark the room as "blue," indicating it is cleared of items. If you have the codes ready, you can clear rooms faster and spend less time in high-risk zones. This is particularly useful for achieving S+ ranks, where time is the most important factor.

In the Second Run, the statue medallions should be your top priority. Since the RPD layout is slightly more aggressive with enemy placement in Scenario B, getting through the Goddess Statue door as quickly as possible saves both health and ammunition.

Opening every safe and locker is not just about completionism; it is a fundamental part of the survival strategy in Resident Evil 2. Each code represents a step away from vulnerability and a step closer to escaping Raccoon City. By utilizing this guide, you ensure that every resource available is at your disposal, giving you the best possible chance to survive the nightmare.